Vitamin D Research Today is a free monthly online journal that collates and summarizes the latest research about Vitamin D, including details on sources, melanin, benefits, deficiency, supplements, calcium absorption.

Osteomalacia in a hemodialysis patient receiving an active vitamin D sterol.

Hernandez JD, Wesseling K, Boechat MI, Gales B, Salusky IB

David Geffen School of Medicine at UCLA, CA, USA.

BACKGROUND: A 17-year-old Filipino male hemodialysis patient presented for renal transplant evaluation. He had significant skeletal abnormalities characterized by bone pain, an inability to walk, and secondary hyperparathyroidism despite therapy with an active vitamin D sterol (paricalcitol). INVESTIGATIONS: The patient underwent a physical examination, and his serum levels of calcium, phosphorus, alkaline phosphatase, parathyroid hormone, aluminum and 25-hydroxycholecalciferol (25OH-vitamin D) were determined. X-rays of hips and lower extremities, MRI, and bone histomorphometry after double tetracycline labeling were performed. DIAGNOSIS: Osteomalacia associated with low 25OH-vitamin D levels. MANAGEMENT: Monthly therapy with ergocalciferol (vitamin D2) and discontinuation of paricalcitol.

Published 28 March 2007 in Nat Clin Pract Nephrol, 3(4): 227-32.
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