Vitamin D Research Today is a free monthly online journal that collates and summarizes the latest research about Vitamin D, including details on sources, melanin, benefits, deficiency, supplements, calcium absorption.

Modulation of tyrosine phosphorylation signalling pathways by 1alpha,25(OH)2-vitamin D3.

Boland R, Buitrago C, De Boland AR

Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, (8000) Bahía Blanca, Argentina. rboland@criba.edu.ar

Hormonally active vitamin D(3), 1alpha,25(OH)(2)D(3), interacts with the classic vitamin D nuclear receptor that regulates gene transcription and with a putative cell membrane receptor that mediates rapid biological responses. 1alpha,25(OH)(2)D(3) actions on target tissues regulate: mineral metabolism and intracellular Ca(2+); protein kinase cascades leading to cell proliferation, differentiation and apoptosis; muscle growth and contractility; and the immune system. There is evidence for underlying 1alpha,25(OH)(2)D(3)-mediated protein tyrosine phosphorylation signalling in bone, intestine, muscle, epidermal and cancer cells. Extracellular-signal-regulated kinases-1/2, p38 and/or c-jun N-terminal kinase pathways play important roles in mediating 1alpha,25(OH)(2)D(3) actions. Studies to elucidate key regulatory metabolic steps and crosstalk sites in these pathways would enhance our understanding of the significance of tyrosine phosphorylation cascades in normal 1alpha,25(OH)(2)D(3) physiology, pathophysiology and pharmacology.

Published 1 August 2005 in Trends Endocrinol Metab, 16(6): 280-7.
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